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NRF2-addicted cancer cells are very well adapted to the greatly enhanced generation of antioxidant and detoxification capacity by establishing unique metabolism

Due to the lack of comprehensive studies on natural compounds, little is known about their dosing and side effect profiles

The tested animals that were listed in the patent include rats, mice, rabbits, guinea pigs and pigs, as well as a single study in humans

Protein concentrations were determined using the BCA assay kit (Thermo Fisher Scientific, #23225) following the manufacturers protocol

Fetch of Hesperidin and carriers The three-dimensional (3D) structure of the drug and the carriers (glyceryl monostearate, chitosan, poloxamer 188 & TPGS) were fetched and salvaged with the help of PubChem database ( in the form of smiles notations